Nanodisc Platform

Nanodiscs are synthetic lipid bilayer systems constructed from membrane scaffold proteins (MSPs) and phospholipids. They provide a near-physiological native microenvironment for membrane proteins, stabilizing their native conformations.

Distolife provides Nanodisc assembly services, including membrane protein reassembly, MSP system optimization, phospholipid system screening, and reconstitution condition optimization. Applicable to GPCRs, ion channels, transporters, and other complex membrane proteins, our services support protein stability studies, functional assays, structural determination, and drug-binding studies.

Service Content:

Membrane protein reassembly
MSP system optimization
Phospholipid system screening
Optimization of reconstitution conditions

Suitable for:

GPCRs
Ion channels
Transporters
Other complex membrane proteins

Applications:

Protein stability studies
Functional assays
Structural analysis
Drug binding studies

Service and Duration:

Service Details	Lead Time
Establishment of the nanodisc system	4–8 Weeks

Service Delivery Standards:

Protein stability assessment data;
SEC analysis results;
Monodispersity assessment results;
Nanodisc assembly verification data;
Electron microscopy or other structural characterization data (based on project requirements).
Reconstituted nanodisc samples;
Information on MSP and lipid systems;