Cryo-EM Research
Relying on mature membrane protein preparation and cryo-EM technology platforms, Distolife offers a comprehensive, end-to-end solution from sample preparation to 3D structural determination. We conduct technical route evaluations and continuously optimize sample homogeneity and cryo-grid preparation conditions.
This full-process service—from membrane protein preparation to structural analysis—supports the elucidation of target mechanism of action (MoA), analysis of drug binding modes, and rational drug design & development.
Service Workflow
Membrane protein preparation
Sample quality assessment
Negative staining screening
Cryo-sample preparation
Cryo-EM data acquisition
Structure reconstruction and analysis
Supported Research Targets:
- GPCR-G protein complexes
- Ion channels
- Transporters
- Membrane protein-ligand complexes
- Membrane protein-antibody complexes
Service and Duration (Overall timeframe approximately 2–3 months):
| Service Details | Lead Time |
| Sample evaluation | 2–3 weeks |
| Negative-stain screening | 2–3 weeks |
| Cryo-EM data acquisition | 3–6 Weeks |
| Data processing and analysis | 4–8 Weeks |
Service Delivery Standards:
- Sample quality assessment report;
- Negative-stain images;
- Raw Cryo-EM data;
- Data processing report;
- 3D reconstruction results;
- Resolution assessment;
- Structural analysis report;
- Frozen samples;
- Remaining protein samples.
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