Detergent Services
Membrane proteins are highly susceptible to conformational changes and loss of biological activity once removed from their native lipid environment; choosing the appropriate detergent is therefore crucial to maintaining their structural and functional integrity.
Distolife possesses a mature system for membrane protein detergent screening and stability optimization. Through multi-type detergent combinatorial screening, we enhance membrane protein solubility, stability, monodispersity, and biological activity. Our services encompass detergent condition screening, buffer system optimization, and protein stability evaluation.
Service Content:
- Screening of detergent conditions
- Optimization of buffer systems
- Evaluation of protein stability
Service and Duration:
| Service Details | Lead Time |
| Detergent Screening and Optimization | 2–6 Weeks |
Service Delivery Standards:
- Screening results for various detergent conditions;
- Protein stability evaluation data;
- SEC analysis results;
- Monodispersity evaluation results;
- Cryo-EM or other structural characterization data(based on project requirments);
- Optimized membrane protein sample.
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